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Phenotypes Associated with This Genotype
Genotype
MGI:3793780
Allelic
Composition
Atp7aMo-br/Y
Genetic
Background
involves: C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7aMo-br mutation (2 available); any Atp7a mutation (75 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• significant reduction in serum copper (mostly found in ceruplasmin) in males is observed
• brain levels are reduced by 66% compared to wild-type males
• copper levels in brain are reduced by 40%
• 7-10 day-old males show an accumulation of copper in the intestinal wall
• 7-10 day-old males have significantly reduced (by >2-fold) liver copper levels

liver/biliary system
• 7-10 day-old males have significantly reduced (by >2-fold) liver copper levels

nervous system
• copper levels in brain are reduced by 40%

Mouse Models of Human Disease
OMIM ID Ref(s)
Menkes Disease 309400 J:5462


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory