Mouse Genome Informatics
ot
    Atp7aMo-br/Y
involves: C57BL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
homeostasis/metabolism
• significant reduction in serum copper (mostly found in ceruplasmin) in males is observed (J:5462)
• brain levels are reduced by 66% compared to wild-type males (J:5462)
• copper levels in brain are reduced by 40% (J:5462)
• 7-10 day-old males show an accumulation of copper in the intestinal wall (J:5462)
• 7-10 day-old males have significantly reduced (by >2-fold) liver copper levels (J:5462)

liver/biliary system
• 7-10 day-old males have significantly reduced (by >2-fold) liver copper levels (J:5462)

nervous system
• copper levels in brain are reduced by 40% (J:5462)

Mouse Models of Human Disease
OMIM IDRef(s)
Menkes Disease 309400 J:5462