Mouse Genome Informatics
hm
    Airetm1.1Doi/Airetm1.1Doi
SJL.129S2-Airetm1.1Doi/Doi
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• Background Sensitivity: sialitis is observed in all mice by 20 weeks of age which is a much higher incidence than what is observed when the mutant allele is on the C57BL/6 or BALB/c backgrounds
• Background Sensitivity: gastritis occurs in all mice by 20 weeks of age but is rarely observed when the mutant allele is on the C57BL/6 background
• 71% of mice exhibit inflammation of the pancreas on this background while no inflammation is observed in C57BL/6 or BALB/c mice carrying this mutant allele
• all mice have inflammation of the prostate by 20 weeks of age (J:107432)
• Background Sensitivity: mice generate autoantibodies with a reactivity that mirror the histopathology associated with this mouse strain
• Background Sensitivity: liver inflammation is observed in 83% of mice by 20 weeks of age while no inflammation is present when the mutant allele is on the C57BL/6 background
• Background Sensitivity: 50% of mice exhibit inflammation of the ovaries on this background while no inflammation is observed in C57BL/6 mice carrying the mutant allele (J:107432)
• Background Sensitivity: lung inflammation is observed in 100% of mice by 20 weeks of age which is a much higher incidence than observed when the mutant allele is on the C57BL/6 background

endocrine/exocrine glands
• Background Sensitivity: sialitis is observed in all mice by 20 weeks of age which is a much higher incidence than what is observed when the mutant allele is on the C57BL/6 or BALB/c backgrounds
• 71% of mice exhibit inflammation of the pancreas on this background while no inflammation is observed in C57BL/6 or BALB/c mice carrying this mutant allele
• all mice have inflammation of the prostate by 20 weeks of age (J:107432)

digestive/alimentary system
• Background Sensitivity: sialitis is observed in all mice by 20 weeks of age which is a much higher incidence than what is observed when the mutant allele is on the C57BL/6 or BALB/c backgrounds
• Background Sensitivity: gastritis occurs in all mice by 20 weeks of age but is rarely observed when the mutant allele is on the C57BL/6 background

liver/biliary system
• Background Sensitivity: liver inflammation is observed in 83% of mice by 20 weeks of age while no inflammation is present when the mutant allele is on the C57BL/6 background

reproductive system
• all mice have inflammation of the prostate by 20 weeks of age (J:107432)
• Background Sensitivity: 50% of mice exhibit inflammation of the ovaries on this background while no inflammation is observed in C57BL/6 mice carrying the mutant allele (J:107432)

respiratory system
• Background Sensitivity: lung inflammation is observed in 100% of mice by 20 weeks of age which is a much higher incidence than observed when the mutant allele is on the C57BL/6 background

Mouse Models of Human Disease
OMIM IDRef(s)
Autoimmune Polyendocrine Syndrome, Type I, with or without Reversible Metaphyseal Dysplasia; APS1 240300 J:107432