Mouse Genome Informatics
hm
    Airetm1.1Doi/Airetm1.1Doi
C.129S2-Airetm1.1Doi/Doi
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• sialitis is observed in 20% of mice by 20 weeks of age which is a much lower incidence than what is observed when the mutant allele is on other backgrounds
• gastritis occurs in all mice by 20 weeks of age but is rarely observed in when the mutant allele is on the C57BL/6 background
• all mice have inflammation of the prostate by 20 weeks of age (J:107432)
• Background Sensitivity: mice generate autoantibodies with a reactivity that mirror the histopathology associated with this mouse strain
• Background Sensitivity: the autoantibodies from this strain consistently target stomach antigens with reactivity patterns distinctly different from the autoantibodies generated on the NOD background
• Background Sensitivity: cornea inflammation occurs in 60% of mice of this background by 20 weeks of age but is not observed when the mutant allele is on SJL or C57BL/6 background
• Background Sensitivity: liver inflammation is observed in 40% of mice by 20 weeks of age while no inflammation is present when the mutant allele is on the C57BL/6 background
• Background Sensitivity: all mice exhibit inflammation of the ovaries on this background but while no inflammation is observed in C57BL/6 mice carrying the mutant allele (J:107432)
• Background Sensitivity: lung inflammation is observed in 50% of mice by 20 weeks of age which is a much lower incidence than observed when the mutant allele is on the NOD or SJL backgrounds

vision/eye
• Background Sensitivity: cornea inflammation occurs in 60% of mice of this background by 20 weeks of age but is not observed when the mutant allele is on SJL or C57BL/6 background
• retinal degeneration resulting from autoimmune disease occurs by 20 weeks of age in 93% of mice

endocrine/exocrine glands
• sialitis is observed in 20% of mice by 20 weeks of age which is a much lower incidence than what is observed when the mutant allele is on other backgrounds
• all mice have inflammation of the prostate by 20 weeks of age (J:107432)

digestive/alimentary system
• sialitis is observed in 20% of mice by 20 weeks of age which is a much lower incidence than what is observed when the mutant allele is on other backgrounds
• gastritis occurs in all mice by 20 weeks of age but is rarely observed in when the mutant allele is on the C57BL/6 background

liver/biliary system
• Background Sensitivity: liver inflammation is observed in 40% of mice by 20 weeks of age while no inflammation is present when the mutant allele is on the C57BL/6 background

reproductive system
• all mice have inflammation of the prostate by 20 weeks of age (J:107432)
• Background Sensitivity: all mice exhibit inflammation of the ovaries on this background but while no inflammation is observed in C57BL/6 mice carrying the mutant allele (J:107432)

respiratory system
• Background Sensitivity: lung inflammation is observed in 50% of mice by 20 weeks of age which is a much lower incidence than observed when the mutant allele is on the NOD or SJL backgrounds

Mouse Models of Human Disease
OMIM IDRef(s)
Autoimmune Polyendocrine Syndrome, Type I, with or without Reversible Metaphyseal Dysplasia; APS1 240300 J:107432