About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3793503
Allelic
Composition
Lrp5tm1Kry/Lrp5tm1Kry
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5tm1Kry mutation (0 available); any Lrp5 mutation (81 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• hyperpermeable retinal vessels (J:135279)
• reduced density of retinal small vessels and capillaries and an attenuated and abnormally patterned vasculature due to incomplete development (J:135279)
• at P7, retinal vascular density is reduced compared to in wild-type retina (J:144980)
• associated with reduced rate of entry into the cell cycle (J:101493)
• persists on both a normal chow and low tryptophan diet (J:146078)

homeostasis/metabolism
• when fed a diet containing 75% less tryptophan than normal, circulating serotonin levels are reduced 8- to 10-fold
• circulating serotonin levels increase with age

skeleton
N
• despite the decrease in osteoblast numbers in vivo, osteoblast proliferation ex vivo is normal
• on a normal diet bone mass is reduced
• when fed a diet containing 75% less tryptophan than normal, bone mass is normalized
• variable reduction in mineralization of phalanges at P0, with incomplete penetrance

cardiovascular system
• hyperpermeable retinal vessels (J:135279)
• reduced density of retinal small vessels and capillaries and an attenuated and abnormally patterned vasculature due to incomplete development (J:135279)
• at P7, retinal vascular density is reduced compared to in wild-type retina (J:144980)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory