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Phenotypes Associated with This Genotype
Genotype
MGI:3793301
Allelic
Composition
Tg(IghelMD4)4Ccg/Tg(IghelMD4)4Ccg
Genetic
Background
NOD.B6-Tg(IghelMD4)4Ccg/DvsJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghelMD4)4Ccg mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the number of CD8 T cells found in the spleen is half that of non-transgenic NOD mice
• the number but not the proportion of B cells found in the spleen is twice that of non-transgenic NOD mice (J:80859)
• 99.3% of these B cells express the transgenic IgM B cell receptor specific for hen egg lysozyme (J:80859)
• 8.4% of the B cells express endogenous IgM indicating there is some escape from allelic exclusion (J:80859)
• 98% of the B cells express the transgenic antibody that is specific for hen egg lysozyme (HEL) (J:89156)
• 94% of these B cells retain the ability to bind HEL protein (J:89156)
• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD
• 90% of female mice are diabetic by 30 weeks of age which is similar to the incidence rate in non-transgenic NOD mice
• there is a significant delay in time of onset compared to non-transgenic diabetic mice

hematopoietic system
• the number of CD8 T cells found in the spleen is half that of non-transgenic NOD mice
• the number but not the proportion of B cells found in the spleen is twice that of non-transgenic NOD mice (J:80859)
• 99.3% of these B cells express the transgenic IgM B cell receptor specific for hen egg lysozyme (J:80859)
• 8.4% of the B cells express endogenous IgM indicating there is some escape from allelic exclusion (J:80859)
• 98% of the B cells express the transgenic antibody that is specific for hen egg lysozyme (HEL) (J:89156)
• 94% of these B cells retain the ability to bind HEL protein (J:89156)
• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:80859


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory