Mouse Genome Informatics
hm
    Ighmtm1Cgn/Ighmtm1Cgn
NOD.129S2-Ighmtm1Cgn/DvsJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• B cells are absent in the spleen
• the proportion, but not the number, of CD 4 and CD8 T cells found in the spleen is increased due to the absence of B cells
• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD
• follicles do not develop in the spleen
• 13.6% of female mice develop diabetes by 21 weeks of age compared to control NOD mice that have an incidence rate of 95.5% at this age

hematopoietic system
• B cells are absent in the spleen
• the proportion, but not the number, of CD 4 and CD8 T cells found in the spleen is increased due to the absence of B cells
• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD
• follicles do not develop in the spleen

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:80859