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Phenotypes Associated with This Genotype
Genotype
MGI:3793300
Allelic
Composition
Ighmtm1Cgn/Ighmtm1Cgn
Genetic
Background
NOD.129S2-Ighmtm1Cgn/DvsJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (19 available); any Ighm mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• B cells are absent in the spleen
• the proportion, but not the number, of CD 4 and CD8 T cells found in the spleen is increased due to the absence of B cells
• follicles do not develop in the spleen
• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD
• 13.6% of female mice develop diabetes by 21 weeks of age compared to control NOD mice that have an incidence rate of 95.5% at this age

hematopoietic system
• B cells are absent in the spleen
• the proportion, but not the number, of CD 4 and CD8 T cells found in the spleen is increased due to the absence of B cells
• follicles do not develop in the spleen
• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT type 1 diabetes mellitus DOID:9744 OMIM:222100
OMIM:300136
J:80859


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory