Phenotypes Associated with This Genotype

Genotype
MGI:3793300

• Allelic Composition: Ighm^tm1Cgn/Ighm^tm1Cgn
• Genetic Background: NOD.129S2-Ighm^tm1Cgn/DvsJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal T cell proliferation ( J:80859 )

• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD

immune system

abnormal T cell proliferation ( J:80859 )

• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD

absent B cells ( J:80859 )

• B cells are absent in the spleen

abnormal T cell number ( J:80859 )

• the proportion, but not the number, of CD 4 and CD8 T cells found in the spleen is increased due to the absence of B cells

decreased spleen B cell follicle number ( J:80859 )

• follicles do not develop in the spleen

decreased susceptibility to autoimmune diabetes ( J:80859 )

• 13.6% of female mice develop diabetes by 21 weeks of age compared to control NOD mice that have an incidence rate of 95.5% at this age

hematopoietic system

abnormal T cell proliferation ( J:80859 )

• T cells fail to proliferate when splenocytes are cultured in vitro with the diabetes autoantigen GAD

absent B cells ( J:80859 )

• B cells are absent in the spleen

abnormal T cell number ( J:80859 )

• the proportion, but not the number, of CD 4 and CD8 T cells found in the spleen is increased due to the absence of B cells

decreased spleen B cell follicle number ( J:80859 )

• follicles do not develop in the spleen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:80859