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Phenotypes Associated with This Genotype
Genotype
MGI:3790954
Allelic
Composition
Stk11tm1Tpm/Stk11+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk11tm1Tpm mutation (0 available); any Stk11 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• seen in one animal; incidence similar to age-matched controls

liver/biliary system
• seen in one animal; incidence similar to age-matched controls
• small number of tumors and neoplasias are observed in various organs including multiple liver adenomas in mice 6-20 months of age; incidence similar to age-matched controls

mortality/aging
• 80% die by 16 months of age

growth/size/body
• noted as mice age

digestive/alimentary system
• grossly distended by large polyps
• all mice >6 months of age have macroscopic gastrointestinal polyps; majority are found in glandular stomach with equal distribution in fundus, antrum, and pylorus
• in most animals, 1-3 large polyps (20-30 mm in diameter) originate in pylorus and protrude into duodenum
• all polyps have extensive well-developed smooth muscle component originating from central stalk contiguous with muscularis mucosa
• results from protrusion of large polyps into lumen

neoplasm
• seen in one animal; incidence similar to age-matched controls
• small number of tumors and neoplasias are observed in various organs including multiple liver adenomas in mice 6-20 months of age; incidence similar to age-matched controls
• seen in one animal; incidence similar to age-matched controls
• seen in one animal; incidence similar to age-matched controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Peutz-Jeghers syndrome DOID:3852 OMIM:175200
J:79074


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory