Phenotypes Associated with This Genotype

Genotype
MGI:3790875

• Allelic Composition: Chrna2^tm1Jbou/Chrna2^tm1Jbou
• Genetic Background: B6.129X1-Chrna2^tm1Jbou

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:126075 )

N • in mutant mice, basal synaptic transmission and short-term synaptic plasticity, measured by recording fEPSPs and PPF, is similar to controls

N • conventional theta burst stimulation (TBS) induces robust and stable LTP in Schaffer collateral CA1 synapses, similar to controls

abnormal excitatory postsynaptic currents ( J:126075 )

• in mutant mice, nicotine does not induce nor promote the spread of excitatory neural activity from the Schaffer collateral pathway as measured by fEPSPs and optical fluorescence

abnormal inhibitory postsynaptic currents ( J:126075 )

• in mutant mice, nicotine does not promote the spread of inhibitory neural activity from the temporoammonic pathway as measured by fEPSPs and optical fluorescence

abnormal long-term potentiation ( J:126075 )

• in Schaffer collateral CA1 synapses, nicotine induced facilitation of theta-burst stimulated LTP induction is supressed

• in temporoammonic CA1 synapses, nicotine supression of LTP induction is eliminated

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:126075 )

• in mutant mice, nicotine fails to facilitate LTP in the Schaffer collateral pathway and fails to supress LTP induction in the temporoammonic pathway

• nicotine fails to induce and promote the spread of excitatory activity in the Schaffer collateral pathway and fails to supress inhibitory activity in the temporoammonic pathway