Mouse Genome Informatics
tg
    Tg(H2-Ea-G6pc2)69Tkay/?
NOD-Tg(H2-Ea-G6pc2)69Tkay
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• mice develop insulitis with similar incidence and severity as non-transgenic controls
• G6pc2206-214-specific CD8+ T cells transferred from Tg(TcraTcrbNY8.3)1Pesa NOD mice proliferate extensively in peripheral and other lymph nodes
• T cells specific for IGRP206-214 (G6pc2206-214) are not detected in peripheral blood
• a complete absence of G6pc2206-214-specific CD8+ T cells is observed in expanded, cultured islet-infiltrating T cells compared to 40% of cultured T cells from control littermates
• no spontaneous CD4+ T cell response by cultured splenocytes exposed to G6pc24-22 peptide is detected in contrast to wild-type NOD mice
• expanded T cells from pancreatic islets demonstrate tolerance to MHC class I and II-restricted G6pc2 peptides
• mice develop Type I diabetes at rate similar to wild-type NOD controls
• insulin autoantibodies are elevated in 12-week old transgenic animals, similar to control wild-type NOD mice

hematopoietic system
• G6pc2206-214-specific CD8+ T cells transferred from Tg(TcraTcrbNY8.3)1Pesa NOD mice proliferate extensively in peripheral and other lymph nodes
• T cells specific for IGRP206-214 (G6pc2206-214) are not detected in peripheral blood
• a complete absence of G6pc2206-214-specific CD8+ T cells is observed in expanded, cultured islet-infiltrating T cells compared to 40% of cultured T cells from control littermates
• no spontaneous CD4+ T cell response by cultured splenocytes exposed to G6pc24-22 peptide is detected in contrast to wild-type NOD mice

endocrine/exocrine glands
• mice develop insulitis with similar incidence and severity as non-transgenic controls

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:117352