Phenotypes Associated with This Genotype

Genotype
MGI:3790751

• Allelic Composition: Chrna10^tm1Jbou/Chrna10^tm1Jbou
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:130585 )

N • no differences in baseline auditory brainstem responses (ABRs), summed activity of auditory neurons evoked by short tone pips or in distortion product autoacoustic emissions (DPOAEs)

abnormal cochlear hair cell morphology ( J:130585 )

abnormal cochlear IHC efferent innervation pattern ( J:130585 )

• the inner spiral bundle appears disorganized

• modiolar-side terminals are larger than controls

• fewer terminals on the pillar side of the hair cell

abnormal cochlear OHC efferent innervation pattern ( J:130585 )

• efferent terminals contacting OHCs are larger in size but fewer in number than controls

• 50% of OHCs had more than one synaptic terminal

abnormal cochlear hair cell physiology ( J:130585 )

abnormal cochlear inner hair cell physiology ( J:130585 )

• both inward and outward currents elicited by the application of acetycholinesterase are not detectable

• synaptic currents elicited by the superfusion of KCl to depolarize synaptic terminals are not detectable

abnormal cochlear outer hair cell physiology ( J:130585 )

• inward currents elicited by the application of acetycholinesterase are either not detectable or reduced

• outward currents elicited by the application of acetycholinesterase are either not detectable or reduced

• synaptic currents elicited by the superfusion of KCl to depolarize synaptic terminals are not detectable

• small inward currents are detected when both KCl and acetylcholinesterase are applied; nicotine did not evoke currents in OHCs that were responsive to ACh

abnormal distortion product otoacoustic emission ( J:130585 )

• a during-shocks enhancement was observed; after shock-train offset, amplitudes and offset time constants were similar to controls

• efferent-evoked supression of DPOAEs was never observed

nervous system

abnormal cochlear hair cell morphology ( J:130585 )

abnormal cochlear IHC efferent innervation pattern ( J:130585 )

• the inner spiral bundle appears disorganized

• modiolar-side terminals are larger than controls

• fewer terminals on the pillar side of the hair cell

abnormal cochlear OHC efferent innervation pattern ( J:130585 )

• efferent terminals contacting OHCs are larger in size but fewer in number than controls

• 50% of OHCs had more than one synaptic terminal

abnormal cochlear hair cell physiology ( J:130585 )

abnormal cochlear inner hair cell physiology ( J:130585 )

• both inward and outward currents elicited by the application of acetycholinesterase are not detectable

• synaptic currents elicited by the superfusion of KCl to depolarize synaptic terminals are not detectable

abnormal cochlear outer hair cell physiology ( J:130585 )

• inward currents elicited by the application of acetycholinesterase are either not detectable or reduced

• outward currents elicited by the application of acetycholinesterase are either not detectable or reduced

• synaptic currents elicited by the superfusion of KCl to depolarize synaptic terminals are not detectable

• small inward currents are detected when both KCl and acetylcholinesterase are applied; nicotine did not evoke currents in OHCs that were responsive to ACh