Phenotypes Associated with This Genotype

Genotype
MGI:3789315

• Allelic Composition: En1^tm5(en)Alj/En1⁺; En2^tm2Alj/En2^tm2Alj
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased inferior colliculus size ( J:134516 )

• reduced in size at E18.5

abnormal cerebellum morphology ( J:134516 )

• in posterior hemisphere crusil and paramedian folia are fused; in one embryo, a partial fissure separating crusil and paramedian folia is observed

abnormal cerebellar foliation ( J:134516 )

• foliation defects are milder than in En1^tm2Alj /+, En2^tm2Alj homozygotes; most mutants have foliation pattern similar to hemispheres of En2^tm2Alj homozygotes

abnormal cerebellum posterior vermis morphology ( J:134516 )

• subregion VIII (posterior vermis) is not present at E18.5

small cerebellum ( J:134516 )

• at E18.5, reduced in overall size by one-third relative to controls