Phenotypes for En1 En2 MGI:3789303 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	En1^tm2Alj/En1⁺ En2^tm2Alj/En2⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm2Alj mutation (1 available); any En1 mutation (32 available)
En2^tm2Alj mutation (0 available); any En2 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar foliation ( J:134516 )

• delay in cerebellum foliation is observed in adult mice

abnormal cerebellum vermis morphology ( J:134516 )

• in E18.5 mutants, there is a general delay in fissure formation in vermis; less severe than in En2^tm2Alj homozygotes

abnormal cerebellum anterior vermis morphology ( J:134516 )

• vermis displays fused folia, and folia I, II, and III are smaller than normal in adults

abnormal cerebellum posterior vermis morphology ( J:134516 )

• folium VIII is positioned between lobule VII and IX; folium VIII position is shifted posteriorly but less than in En2^tm2Alj homozygotes

small cerebellum ( J:134516 )

• reduced in size

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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