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Phenotypes Associated with This Genotype
Genotype
MGI:3789197
Allelic
Composition
Lama2tm1Stk/Lama2tm1Stk
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd * BALB/c * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lama2tm1Stk mutation (1 available); any Lama2 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die of undetermined causes by 5 weeks of age (J:43145)
• mice die of undetermined causes by 5 weeks of age (J:43145)

muscle
• by P21 and P28, proliferation of endomysial connective tissue is observed (J:43145)
• by P21 and P28, proliferation of endomysial connective tissue is observed (J:43145)
• the number of apoptotic nuclei in muscle fibers is increased compared to in wild-type mice (J:43145)
• the number of apoptotic nuclei in muscle fibers is increased compared to in wild-type mice (J:43145)
• by P21 and P28, muscle fibers of different calibers are apparent (J:43145)
• by P21 and P28, muscle fibers of different calibers are apparent (J:43145)
• by P24 mice exhibit dystrophic symptoms including a waddling gait and twitching (J:43145)
• by P24 mice exhibit dystrophic symptoms including a waddling gait and twitching (J:43145)
• by P24 mice exhibit twitching (J:43145)
• by P24 mice exhibit twitching (J:43145)
• by P9 mice exhibit scattered degeneration of muscle fibers and at P11 numerous degenerating fibers with extensive infiltrate are observed (J:43145)
• degeneration is accompanied by regeneration at P13 (J:43145)
• by P9 mice exhibit scattered degeneration of muscle fibers and at P11 numerous degenerating fibers with extensive infiltrate are observed (J:43145)
• degeneration is accompanied by regeneration at P13 (J:43145)

behavior/neurological
• by P24 mice exhibit a waddling gait (J:43145)
• by P24 mice exhibit a waddling gait (J:43145)

growth/size/body
• beginning at P14 and continuing for the rest of their lives (J:43145)
• beginning at P14 and continuing for the rest of their lives (J:43145)
• apparent after postnatal day 14 (J:43145)
• apparent after postnatal day 14 (J:43145)

cellular
• the basal lamina is nearly completely absent around muscle fibers and Schwann cells of peripheral nerves (J:43145)
• the basal lamina is nearly completely absent around muscle fibers and Schwann cells of peripheral nerves (J:43145)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory