Analysis Tools
vision/eye
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• mice 7 days of age display angiectasis and vascular leakage in the mid-periphery of the retina
• mice 14 days of age have areas of the retina that are not perfused with capillaries
• abnormal blood vessels are found in the vitreous outside of the inner-limiting membrane in young mice
• other blood vessels in the retina of young mice have a tortured appearance
• vessel abnormalities lessen with age with the retina vasculature appearing normal by 84 days of age
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• vascular leakage is observed in the retinas of mice starting at 7 days of age
• vessel abnormalities lessen with age with the retina vasculature appearing normal by 84 days of age
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cardiovascular system
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• mice 7 days of age display angiectasis and vascular leakage in the mid-periphery of the retina
• mice 14 days of age have areas of the retina that are not perfused with capillaries
• abnormal blood vessels are found in the vitreous outside of the inner-limiting membrane in young mice
• other blood vessels in the retina of young mice have a tortured appearance
• vessel abnormalities lessen with age with the retina vasculature appearing normal by 84 days of age
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• the left ventricular volume of 3-4 month old mice is reduced
• hypertrophic growth of the left ventricle induced by pressure overload is significantly reduced compared to wild-type controls
• end diastolic volumes increased in response to pressure overload compared to wild-type mice that have decreased diastolic volumes
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• vascular leakage is observed in the retinas of mice starting at 7 days of age
• vessel abnormalities lessen with age with the retina vasculature appearing normal by 84 days of age
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• left ventricle contractility decreased in response to pressure overload compared to the increases observed in wild-type mice
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hematopoietic system
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• stress-induced increase in microglial cell surface, which is a marker of activation, is significantly reduced by 1.5 to 3 fold in these mice
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immune system
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• stress-induced increase in microglial cell surface, which is a marker of activation, is significantly reduced by 1.5 to 3 fold in these mice
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nervous system
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• stress-induced increase in microglial cell surface, which is a marker of activation, is significantly reduced by 1.5 to 3 fold in these mice
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• the total volume of infarction caused by hypoxia-ischemia (HI) was reduced from 53% in wild-type mice to 42% in these mice
• the neuropathological scores to measure brain injury resulting from HI were reduced with the most marked reduction of 35% occurring in the cerebral cortex
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homeostasis/metabolism
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• the total volume of infarction caused by hypoxia-ischemia (HI) was reduced from 53% in wild-type mice to 42% in these mice
• the neuropathological scores to measure brain injury resulting from HI were reduced with the most marked reduction of 35% occurring in the cerebral cortex
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muscle
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• left ventricle contractility decreased in response to pressure overload compared to the increases observed in wild-type mice
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