Phenotypes Associated with This Genotype

Genotype
MGI:3785289

• Allelic Composition: Cybb^tm1Din/Cybb^tm1Din
• Genetic Background: B6.129S-Cybb^tm1Din

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:113463 )

♀N • mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis

increased acute inflammation ( J:110181 )

♀ • increased infiltration of leukocytes into gelatin sponge implanted along with QR-32 fibrosarcoma cells

granulomatous inflammation ( J:146231 )

♀ • zymosan injection into the peritoneal cavity results in an exaggerated influx of polymorphonuclear cells with declining numbers over the next 96 hours

♀ • macrophage numbers also become elevated and remain elevated for 96 hours

nervous system

reduced long-term potentiation ( J:111410 )

♀ • completely abrogated in hippocampal slices

decreased post-tetanic potentiation ( J:111410 )

♀ • significantly decreased

♀ • synaptic fatigue is normal

behavior/neurological

abnormal spatial learning ( J:111410 )

♀ • small but significant deficits in early training trials in water maze tests

♀ • spatial learning impairments

impaired coordination ( J:111410 )

♀ • very slightly impaired motor coordination in a rotarod test

decreased vertical activity ( J:111410 )

♀ • less rearing in open field tests

neoplasm

decreased metastatic potential ( J:110181 )

♀ • decreased metastasis of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation

♀ • greatly decreased metastasis of B16BL6 melanoma cells after implantation although cell growth was similar to that seen in controls

decreased tumor growth/size ( J:110181 )

♀ • reduced growth of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic granulomatous disease		DOID:3265	OMIM:PS306400	J:146231