About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3785289
Allelic
Composition
Cybbtm1Din/Cybbtm1Din
Genetic
Background
B6.129S-Cybbtm1Din
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cybbtm1Din mutation (1 available); any Cybb mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis
• increased infiltration of leukocytes into gelatin sponge implanted along with QR-32 fibrosarcoma cells
• zymosan injection into the peritoneal cavity results in an exaggerated influx of polymorphonuclear cells with declining numbers over the next 96 hours
• macrophage numbers also become elevated and remain elevated for 96 hours

nervous system
• completely abrogated in hippocampal slices
• significantly decreased
• synaptic fatigue is normal

behavior/neurological
• small but significant deficits in early training trials in water maze tests
• spatial learning impairments
• very slightly impaired motor coordination in a rotarod test
• less rearing in open field tests

neoplasm
• reduced growth of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation
• decreased metastasis of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation
• greatly decreased metastasis of B16BL6 melanoma cells after implantation although cell growth was similar to that seen in controls

Mouse Models of Human Disease
OMIM ID Ref(s)
Granulomatous Disease, Chronic, X-Linked; CDGX 306400 J:146231


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory