Mouse Genome Informatics
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    Cybbtm1Din/Cybbtm1Din
B6.129S-Cybbtm1Din
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis
• increased infiltration of leukocytes into gelatin sponge implanted along with QR-32 fibrosarcoma cells
• zymosan injection into the peritoneal cavity results in an exaggerated influx of polymorphonuclear cells with declining numbers over the next 96 hours
• macrophage numbers also become elevated and remain elevated for 96 hours

nervous system
• completely abrogated in hippocampal slices
• significantly decreased
• synaptic fatigue is normal

behavior/neurological
• small but significant deficits in early training trials in water maze tests
• spatial learning impairments
• very slightly impaired motor coordination in a rotarod test
• less rearing in open field tests

tumorigenesis
• decreased metastasis of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation
• greatly decreased metastasis of B16BL6 melanoma cells after implantation although cell growth was similar to that seen in controls
• reduced growth of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation

Mouse Models of Human Disease
OMIM IDRef(s)
Granulomatous Disease, Chronic, X-Linked; CGD 306400 J:146231