Mouse Genome Informatics
hm
    Cybbtm1Din/Cybbtm1Din
B6.129S-Cybbtm1Din
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
N
• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis (J:113463)
• increased infiltration of leukocytes into gelatin sponge implanted along with QR-32 fibrosarcoma cells (J:110181)
• zymosan injection into the peritoneal cavity results in an exaggerated influx of polymorphonuclear cells with declining numbers over the next 96 hours (J:146231)
• macrophage numbers also become elevated and remain elevated for 96 hours (J:146231)

nervous system
• completely abrogated in hippocampal slices (J:111410)
• significantly decreased (J:111410)
• synaptic fatigue is normal (J:111410)

behavior/neurological
• small but significant deficits in early training trials in water maze tests (J:111410)
• spatial learning impairments (J:111410)
• very slightly impaired motor coordination in a rotarod test (J:111410)
• less rearing in open field tests (J:111410)

tumorigenesis
• decreased metastasis of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation (J:110181)
• greatly decreased metastasis of B16BL6 melanoma cells after implantation although cell growth was similar to that seen in controls (J:110181)
• reduced growth of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation (J:110181)

Mouse Models of Human Disease
OMIM IDRef(s)
Granulomatous Disease, Chronic, X-Linked; CGD 306400 J:146231