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Phenotypes Associated with This Genotype
Genotype
MGI:3785289
Allelic
Composition
Cybbtm1Din/Cybbtm1Din
Genetic
Background
B6.129S-Cybbtm1Din
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cybbtm1Din mutation (1 available); any Cybb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis (J:113463)
• mice exhibit a normal local Shwartman response namely thrombohemorrhagic vasculitis (J:113463)
• increased infiltration of leukocytes into gelatin sponge implanted along with QR-32 fibrosarcoma cells (J:110181)
• increased infiltration of leukocytes into gelatin sponge implanted along with QR-32 fibrosarcoma cells (J:110181)
• zymosan injection into the peritoneal cavity results in an exaggerated influx of polymorphonuclear cells with declining numbers over the next 96 hours (J:146231)
• macrophage numbers also become elevated and remain elevated for 96 hours (J:146231)
• zymosan injection into the peritoneal cavity results in an exaggerated influx of polymorphonuclear cells with declining numbers over the next 96 hours (J:146231)
• macrophage numbers also become elevated and remain elevated for 96 hours (J:146231)

nervous system
• completely abrogated in hippocampal slices (J:111410)
• completely abrogated in hippocampal slices (J:111410)
• significantly decreased (J:111410)
• synaptic fatigue is normal (J:111410)
• significantly decreased (J:111410)
• synaptic fatigue is normal (J:111410)

behavior/neurological
• small but significant deficits in early training trials in water maze tests (J:111410)
• spatial learning impairments (J:111410)
• small but significant deficits in early training trials in water maze tests (J:111410)
• spatial learning impairments (J:111410)
• very slightly impaired motor coordination in a rotarod test (J:111410)
• very slightly impaired motor coordination in a rotarod test (J:111410)
• less rearing in open field tests (J:111410)
• less rearing in open field tests (J:111410)

tumorigenesis
• decreased metastasis of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation (J:110181)
• greatly decreased metastasis of B16BL6 melanoma cells after implantation although cell growth was similar to that seen in controls (J:110181)
• decreased metastasis of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation (J:110181)
• greatly decreased metastasis of B16BL6 melanoma cells after implantation although cell growth was similar to that seen in controls (J:110181)
• reduced growth of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation (J:110181)
• reduced growth of QR-32 fibrosarcoma cells implanted with a gelatin sponge to induce inflammation (J:110181)

Mouse Models of Human Disease
OMIM ID Ref(s)
Granulomatous Disease, Chronic, X-Linked; CGD 306400 J:146231


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory