Phenotypes Associated with This Genotype

Genotype
MGI:3783759

• Allelic Composition: mt-Rnr2^m1Dwa
• Genetic Background: C3H/An-mt-Rnr2^m1Dwa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:133576 )

• some mice die in utero

neonatal lethality, incomplete penetrance ( J:133576 )

• all but one mouse died within 12 hours of birth

postnatal lethality, complete penetrance ( J:133576 )

• the one mouse that survived P1 died at P11

muscle

abnormal myocardial fiber morphology ( J:133576 )

• myocardial fibers contain atypical, enlarged mitochondria with inclusions and a paucity of normal sacromeres

dilated cardiomyopathy ( J:133576 )

• in neonates

abnormal skeletal muscle fiber morphology ( J:133576 )

• fibers contain an over-proliferation of mitochondria that displaces contractile elements

• mitochondrial within muscle fibers are enlarged and some contain inclusions

myopathy ( J:133576 )

• skeletal muscles exhibit a loss of muscle fibers and contain abnormal mitochondria

cardiovascular system

abnormal myocardial fiber morphology ( J:133576 )

• myocardial fibers contain atypical, enlarged mitochondria with inclusions and a paucity of normal sacromeres

abnormal heart atrium morphology ( J:133576 )

• the atrial wall is thin in neonates

increased heart atrium size ( J:133576 )

• in neonates

dilated cardiomyopathy ( J:133576 )

• in neonates

growth/size/body

decreased body weight ( J:133576 )

• at birth and P11 in the one mouse that survived P1

postnatal growth retardation ( J:133576 )

• in the one mouse that survived P1

fetal growth retardation ( J:133576 )

• at E15.5 and E17.5

integument

delayed hair appearance ( J:133576 )

• in the one mouse that survived P1