Phenotypes Associated with This Genotype

Genotype
MGI:3783722

• Allelic Composition: Socs3^tm1Jni/Socs3^tm1Jni
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:57476 )

• mice continue to die through E16.5 when only 1 is recovered

embryonic lethality during organogenesis, incomplete penetrance ( J:57476 )

• mice exhibit embryonic lethality beginning at E12

hematopoietic system

hematopoietic system phenotype ( J:57476 )

N • despite disruptions in embryonic erythropoiesis, adult hematopoiesis is normal in irradiated mice reconstituted with Socs3^tm1Jni cells

abnormal embryonic erythropoiesis ( J:57476 )

• embryos exhibit a shift from more immature populations to more mature, non-proliferative populations of erythroid cells

• in a colony-forming assay, the number of erythroid colony-forming cells, burst-forming cells and IL-3 sensitive multilineage progenitors is decreased 10-fold compared to wild-type while colony size is typically 5 to 10 times larger than colonies from wild type mice

increased erythrocyte cell number ( J:57476 )

• at E12.5, mice exhibit erythrocytosis that increases in frequency with age

increased nucleated erythrocyte cell number ( J:57476 )

• most erythrocytes are still nucleated unlike in wild-type mice

liver/biliary system

abnormal liver morphology ( J:57476 )

• at E12.5, the fetal liver is distorted with an excess of erythroid cells

embryo

decreased embryo size ( J:57476 )

abnormal embryonic erythropoiesis ( J:57476 )

• embryos exhibit a shift from more immature populations to more mature, non-proliferative populations of erythroid cells

• in a colony-forming assay, the number of erythroid colony-forming cells, burst-forming cells and IL-3 sensitive multilineage progenitors is decreased 10-fold compared to wild-type while colony size is typically 5 to 10 times larger than colonies from wild type mice

growth/size/body

decreased embryo size ( J:57476 )

integument

reddish skin ( J:57476 )

• mice exhibit erythmia throughout the embryo including the head and lens of the eye