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Phenotypes Associated with This Genotype
Genotype
MGI:3783534
Allelic
Composition		 Apaf1fog/Apaf1tm1Her
Genetic
Background		 involves: 129S6/SvEvTac * C3H/HeJ * C57BL/6b
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apaf1fog mutation (1 available); any Apaf1 mutation (77 available)
Apaf1tm1Her mutation (1 available); any Apaf1 mutation (77 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neural tube morphology ( J:71086 )
• phenotype observed at E16.5 can include lumbosacral defects along with either exencephaly or cranioschisis
exencephaly ( J:71086 )
• phenotype observed at E16.5 can include exencephaly

craniofacial
cranioschisis ( J:71086 )
• phenotype observed at E16.5 can include cranioschisis

skeleton
cranioschisis ( J:71086 )
• phenotype observed at E16.5 can include cranioschisis

embryo
abnormal neural tube morphology ( J:71086 )
• phenotype observed at E16.5 can include lumbosacral defects along with either exencephaly or cranioschisis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory