Phenotypes Associated with This Genotype

Genotype
MGI:3783421

• Allelic Composition: Mlh1^tm1Wed/Mlh1^tm1Wed
• Genetic Background: involves: 129/Sv * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Mlh1^tm1Wed/Mlh1^tm1Wed mouse testes show spermatogenic failure at or before metaphase of the first meiotic division

mortality/aging

premature death ( J:133352 )

• 50% of mice die by 30 weeks of age and all mice are dead by 64 weeks of age

reproductive system

oligozoospermia ( J:133352 )

♂ • seminiferous tubules are severely depleted of spermatogenic cells

abnormal male meiosis ( J:133352 )

♂ • sperm cells exhibit aberrant spindle configuration and premature chromosome separation during late pachytene and diplotene

♂ • crossing-over foci are reduced 20% to 77% compared to in wild-type mice

arrest of male meiosis ( J:133352 )

♂ • meiosis is arrested at metaphase I and become apoptotic

abnormal meiotic spindle morphology ( J:133352 )

• sperm cells exhibit aberrant spindle configuration during late pachytene and diplotene

female infertility ( J:133352 )

♀

male infertility ( J:133352 )

♂

neoplasm

increased tumor incidence ( J:133352 )

• 34 of 49 mice develop T and B cell lymphomas, 16 mice develop intestinal tumors (11 adenocarcinomas and 7 adenomas) and 4 mice develop squamous basal cell carcinoma of the skin

increased basal cell carcinoma incidence ( J:133352 )

• 4 of 49 mice develop squamous basal cell carcinoma of the skin

increased lymphoma incidence ( J:133352 )

• 34 of 49 mice develop T and B cell lymphomas

integument

increased basal cell carcinoma incidence ( J:133352 )

• 4 of 49 mice develop squamous basal cell carcinoma of the skin

cellular

oligozoospermia ( J:133352 )

♂ • seminiferous tubules are severely depleted of spermatogenic cells