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Phenotypes Associated with This Genotype
Genotype
MGI:3779101
Allelic
Composition
Grhl1tm1Jane/Grhl1tm1Jane
Genetic
Background
involves: BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grhl1tm1Jane mutation (0 available); any Grhl1 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• similar in size at birth and at 2 months of age but significantly smaller than littermate controls at weaning (J:133318)
• similar in size at birth and at 2 months of age but significantly smaller than littermate controls at weaning (J:133318)

cardiovascular system
N
• unlike human patients with striate palmoplantar keratoderma disorder, no evidence of cardiomyopathy is detected (J:133318)
• unlike human patients with striate palmoplantar keratoderma disorder, no evidence of cardiomyopathy is detected (J:133318)

integument
• over 30% of mice lack hair at weaning with the remainder having sparse coats (J:133318)
• extensive regional hair loss is seen when mice are housed with other mice with regrowth when mice are housed alone (J:133318)
• despite the thinner coat, in a tape-stripping test more hairs are removed compared to wild-type controls (J:133318)
• over 30% of mice lack hair at weaning with the remainder having sparse coats (J:133318)
• extensive regional hair loss is seen when mice are housed with other mice with regrowth when mice are housed alone (J:133318)
• despite the thinner coat, in a tape-stripping test more hairs are removed compared to wild-type controls (J:133318)
• delay in coat growth that may be the result of maternal grooming (J:133318)
• delay in coat growth that may be the result of maternal grooming (J:133318)
• over 30% of mice lack hair at weaning with the remainder having sparse coats (J:133318)
• coat remains sparse throughout life (J:133318)
• over 30% of mice lack hair at weaning with the remainder having sparse coats (J:133318)
• coat remains sparse throughout life (J:133318)
• sections of skin from hypotrichotic regions contain empty cysts in telogen follicles (J:133318)
• cleft between the inner and outer root sheath (J:133318)
• depilated hairs have a naked anagen bulb lacking the inner and outer root sheath (J:133318)
• sections of skin from hypotrichotic regions contain empty cysts in telogen follicles (J:133318)
• cleft between the inner and outer root sheath (J:133318)
• depilated hairs have a naked anagen bulb lacking the inner and outer root sheath (J:133318)
• fewer desmosomes are identified in the interfolicular epidermis and unlike in wild-type mice, this number is further reduced after EGTA treatment (J:133318)
• fewer desmosomes are identified in the interfolicular epidermis and unlike in wild-type mice, this number is further reduced after EGTA treatment (J:133318)
• marked thickening of the stratum corneum on the palmoplantar surfaces of the paws (J:133318)
• marked thickening of the stratum corneum on the palmoplantar surfaces of the paws (J:133318)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory