Phenotypes Associated with This Genotype
Allelic Composition |
Mfn1tm1Dcc/Mfn1tm2Dcc
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Genetic Background |
involves: 129 * 129S4/SvJaeSor * Black Swiss |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn1tm1Dcc mutation
(0 available);
any
Mfn1 mutation
(44 available)
Mfn1tm2Dcc mutation
(2 available);
any
Mfn1 mutation
(44 available)
|
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cellular
|
• fibroblast derived from mutant animals exhibit Cre-dependent mitochondrial fragmentation
• loss of mtDNA nucleoids from a significant fraction of mitochondria
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