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Phenotypes Associated with This Genotype
Genotype
MGI:3779082
Allelic
Composition
Mfn1tm1Dcc/Mfn1tm2Dcc
Genetic
Background
involves: 129 * 129S4/SvJaeSor * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn1tm1Dcc mutation (0 available); any Mfn1 mutation (44 available)
Mfn1tm2Dcc mutation (2 available); any Mfn1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• fibroblast derived from mutant animals exhibit Cre-dependent mitochondrial fragmentation
• loss of mtDNA nucleoids from a significant fraction of mitochondria


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory