Mouse Genome Informatics
hm
    Lystbg-2Btlr/Lystbg-2Btlr
C57BL/6J-Lystbg-2Btlr
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
pigmentation
• the coats of mice homozygous for this mutation are a subtle gray color

immune system
• NK cells from homozygous mutatant mice fail to degranulate following antibody stimulation of NKp46 or Ly49H receptors or after exposure to YAC-1 cells or PMA/ionomycin
• homozygous mutant mice are highly susceptible to infection by mouse cytomegalovirus (MCMV)

integument
• the coats of mice homozygous for this mutation are a subtle gray color

hematopoietic system
• NK cells from homozygous mutatant mice fail to degranulate following antibody stimulation of NKp46 or Ly49H receptors or after exposure to YAC-1 cells or PMA/ionomycin

Mouse Models of Human Disease
OMIM IDRef(s)
Chediak-Higashi Syndrome; CHS 214500 J:133617