Mouse Genome Informatics
hm
    Pnpg/Pnpg
involves: C57BL/6 * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• Background Sensitivity: reduced survival to birth but some do survive when DBA/2J is part of the background

homeostasis/metabolism
• reduced purine nucleoside phosphorylase activity in erythrocytes relative to controls

immune system
• numbers in spleen only 41% of control numbers
• 57% reduction
• thymus levels only 14% of control mice
• marked and progressive decline in cellularity observable by 2-3 months of age
• spleen leukocyte response to conA and IL-2 is impaired, being only 18-20% of normal; when adjusted for the reduction in Thy-1+ cells, overall response to conA and IL-2 is 34-38% compared to controls

hematopoietic system
• numbers in spleen only 41% of control numbers
• 57% reduction
• thymus levels only 14% of control mice
• marked and progressive decline in cellularity observable by 2-3 months of age
• spleen leukocyte response to conA and IL-2 is impaired, being only 18-20% of normal; when adjusted for the reduction in Thy-1+ cells, overall response to conA and IL-2 is 34-38% compared to controls

Mouse Models of Human Disease
OMIM IDRef(s)
Purine Nucleoside Phosphorylase Deficiency 613179 J:39328