Mouse Genome Informatics
hm
    Pnpf/Pnpf
C57BL/6J-Pnpf
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
immune system
• marked and progressive decline in cellularity observable by 2-3 months of age
• numbers in spleen only 57% of control numbers
• spleen leukocyte response to conA and IL-2 is impaired, being only 17-28% of normal; when adjusted for reduction in Thy-1+ cells, overall response to conA and IL-2 is 35-57% compared to controls

hematopoietic system
• marked and progressive decline in cellularity observable by 2-3 months of age
• numbers in spleen only 57% of control numbers
• spleen leukocyte response to conA and IL-2 is impaired, being only 17-28% of normal; when adjusted for reduction in Thy-1+ cells, overall response to conA and IL-2 is 35-57% compared to controls

endocrine/exocrine glands
• marked and progressive decline in cellularity observable by 2-3 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Purine Nucleoside Phosphorylase Deficiency 613179 J:39328