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Phenotypes Associated with This Genotype
Genotype
MGI:3778898
Allelic
Composition
Pnpe/Pnpe
Genetic
Background
C57BL/6J-Pnpe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnpe mutation (0 available); any Pnp mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• marked and progressive decline in cellularity observable by 8 months of age
• spleen leukocyte response to conA and IL-2 is somewhat impaired, being 60-69% of normal

hematopoietic system
• marked and progressive decline in cellularity observable by 8 months of age
• spleen leukocyte response to conA and IL-2 is somewhat impaired, being 60-69% of normal

endocrine/exocrine glands
• marked and progressive decline in cellularity observable by 8 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Purine Nucleoside Phosphorylase Deficiency 613179 J:39328


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory