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Phenotypes Associated with This Genotype
Genotype
MGI:3778823
Allelic
Composition
Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl1Gt(XL802)Byg mutation (1 available); any Vangl1 mutation (71 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal orientation of hair cells of the cochlea in Vangl1Gt(XL802)Byg/Vangl1Gt(XL802)Byg embryos

hearing/vestibular/ear
• modest but significant misorientation in all hair cell layers
• however, the number and organization of hair cell rows is not different from wild-type controls

cardiovascular system
N
• unlike mice homozygous for Vangl2Lp alone, nor outflow tract abnormalities are detected

nervous system
N
• unlike mice with mutations in Vangl2, no neural tube defects are detected
• modest but significant misorientation in all hair cell layers
• however, the number and organization of hair cell rows is not different from wild-type controls

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Neural Tube Defects, Susceptibility To; NTD 182940 J:132697


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory