Analysis Tools
behavior/neurological
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• transgenic mice attack intruder mice less frequently and show longer latency to attack than control littermates in a resident-intruder aggression assay
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• transgenic animals exhibit varying degrees of hyperlocomotion
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• mice exhibit stereotypic behaviors including increased repetitive locomotion, repetitive wall leaping, and gnawing whereas leaping is not observed in nontransgenic littermates
• transgenic mice exhibit perseverative episodes of all normal behaviors, consisting of long-duration episodes of stationary single-state behaviors (eating, drinking, grooming, etc) and long-duration episodes of reiterated locomotor-dependent (two state) behavior (ie. locomote- forage- locomote- explore); behavioral duration is about 3-fold greater than in control animals; stationary behavior episodes are also 3-fold greater
• both males and females display nonaggressive, repetitive biting of littermates; such episodes occur during episodes of social grooming, not during aggressive displays or fighting and begins when mice are less than 3 weeks of age
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nervous system
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• brain is anatomically normal, with no discernible change in CNS morphology or neuron number
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• cAMP content is elevated 38% relative to controls
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• cAMP content is elevated 38% relative to controls
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