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Phenotypes Associated with This Genotype
Genotype
MGI:3778211
Allelic
Composition
Dkc1tm2Bsl/Dkc1+
Tg(Gata1-cre)1Sho/0
Genetic
Background
involves: 129/Sv * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkc1tm2Bsl mutation (0 available); any Dkc1 mutation (3 available)
Tg(Gata1-cre)1Sho mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no live embryos are recovered at E9.5 and most have been resorbed at E12.5, with inheritance of the maternally derived mutant allele
• same phenotype is observed when EIIa-cre transgenic males are used

embryo
• after E7.5, apoptotic nuclei are observed in the trophectoderm
• at E8.5 and E9.5, embryos appear morphologically disorganized relative to wild-type
• at E8.5 or E9.5, embryos do not show signs of axial rotation
• after E7.5, embryos become developmentally growth arrested
• at E8.5 and E9.5, embryos are visibly smaller than littermates
• at E8.5 and E9.5, degeneration within the trophectoderm becomes more extensive

growth/size/body
• at E8.5 and E9.5, embryos are visibly smaller than littermates

reproductive system
• females with the deletion on the paternally-inherited allele are unable to transmit the deletion to offspring; only homozygous Dkc1+, cre transgene-negative male and female offspring are obtained when females heterozygous for the deleted allele are crossed to wild-type males

cellular
• after E7.5, apoptotic nuclei are observed in the trophectoderm


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory