Phenotypes Associated with This Genotype

Genotype
MGI:3777977

• Allelic Composition: Gsk3b^tm1Jrw/Gsk3b⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Increased bone mass in Gsk3b^tm1Jrw/Gsk3b⁺ mice

skeleton

enhanced osteoblast differentiation ( J:129364 )

• ex vivo cultures of calvarial osteoblasts exhibit enhanced osteoblast differentiation

increased trabecular bone volume ( J:129364 )

increased compact bone thickness ( J:129364 )

increased bone mass ( J:129364 )

• increase in bone mass is seen in femurs

increased compact bone mass ( J:129364 )

• proximal tibiae show an increase in cortical bone mass, without abnormality in the growth plate

increased trabecular bone mass ( J:129364 )

• proximal tibiae show an increase in trabecular bone mass, without abnormality in the growth plate

abnormal skeleton physiology ( J:129364 )

abnormal osteoblast physiology ( J:129364 )

• ex vivo cultures of calvarial osteoblasts exhibit enhanced osteoblast differentiation and function as determined by alkaline phosphatase, Alizarin red, and von Kossa staining

increased bone ossification ( J:129364 )

• increase in trabecular bone volume and cortical thickness is accompanied by increases in parameters of bone formation

increased bone resorption ( J:129364 )

• bone resorption parameters are enhanced

cellular

enhanced osteoblast differentiation ( J:129364 )

• ex vivo cultures of calvarial osteoblasts exhibit enhanced osteoblast differentiation

abnormal osteoblast physiology ( J:129364 )

• ex vivo cultures of calvarial osteoblasts exhibit enhanced osteoblast differentiation and function as determined by alkaline phosphatase, Alizarin red, and von Kossa staining