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Phenotypes Associated with This Genotype
Genotype
MGI:3777397
Allelic
Composition
Urostm3Rjde/Urostm3Rjde
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Urostm3Rjde mutation (0 available); any Uros mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice have marked accumulation in bones, and display fluorescent erythrodontia
• hepatic, splenic and erythrocytic uroporphyrinogen III synthase (URO-synthase) activity is greatly reduced compared to wild-type

hematopoietic system
N
• 16-18-month old animals show similar ertythrocyte counts, hematocrits, hemoglobin concentrations, mean corpuscular volumes, and total leukocyte counts to wild-type mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Porphyria, Congenital Erythropoietic 263700 J:132542


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory