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Phenotypes Associated with This Genotype
Genotype
MGI:3777292
Allelic
Composition
Wipf3tm1Tta/Wipf3tm1Tta
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wipf3tm1Tta mutation (0 available); any Wipf3 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• ~78% of homozygous mutant sperm heads display an abnormal shape compared to sperm from heterozygotes
• homozygous mutant sperm heads are extremely thin
• at step 16, homozygous mutant spermatids exhibit thinner heads

reproductive system
• male homozygotes display defective sperm development at the latest step of spermatogenesis
• ~78% of homozygous mutant sperm heads display an abnormal shape compared to sperm from heterozygotes
• homozygous mutant sperm heads are extremely thin
• at step 16, homozygous mutant spermatids exhibit thinner heads
• average litter size is 2.5 pups, reduced from litters from heterozygous by wild-type matings
• when male homozygotes are crossed to wild-type females, only 13% of females become pregnant compared to a rate of 86% of females crossed with heterozygous males
• in vitro fertilization experiments show reduced ability of mutant sperm to fertilize oocytes; 24 hours after insemination, only 20% of oocytes have become fertilized by sperm from mutant males, compared to around 80% of oocytes when heterozygous sperm is tested

homeostasis/metabolism
N
• serum testosterone and follicle-stimulating hormone levels are comparable between heterozygous and homozygous animals


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory