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Phenotypes Associated with This Genotype
Genotype
MGI:3776840
Allelic
Composition
Tcf3tm1Zhu/Tcf3tm1Zhu
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1Zhu mutation (0 available); any Tcf3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• the pontine nucleus develops normally

mortality/aging
• survival rates are lower than normal but higher than in Tcfe2a null mice

reproductive system

hematopoietic system
• less than 10% of B cell numbers are found in mice
• however, B cell commitment occurs normally
• hematopoietic stem cells fail to repopulate an irradiated mouse with B cells
• however, T cell development is normal

immune system
• less than 10% of B cell numbers are found in mice
• however, B cell commitment occurs normally


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory