Phenotypes Associated with This Genotype

Genotype
MGI:3776840

• Allelic Composition: Tcf3^tm1Zhu/Tcf3^tm1Zhu
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:125313 )

N • the pontine nucleus develops normally

mortality/aging

premature death ( J:47671 )

• survival rates are lower than normal but higher than in Tcfe2a null mice

reproductive system

female infertility ( J:47671 )

♀

hematopoietic system

decreased B cell number ( J:47671 )

• less than 10% of B cell numbers are found in mice

• however, B cell commitment occurs normally

abnormal hematopoietic stem cell morphology ( J:47671 )

• hematopoietic stem cells fail to repopulate an irradiated mouse with B cells

• however, T cell development is normal

immune system

decreased B cell number ( J:47671 )

• less than 10% of B cell numbers are found in mice

• however, B cell commitment occurs normally