Mouse Genome Informatics
cx
    Pax1un/Pax1+
Tcf3tm1Cmu/Tcf3tm1Cmu

involves: 129P2/OlaHsd * C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most mice die postnatally due to are cannibalization

reproductive system

nervous system
• mice are born with non-lethal neural tube defects at the lumbosacral region over which skin grows

renal/urinary system
• mice exhibit high outflow tract resistance

immune system
• the ratio of CD4 over CD8 T cells is reduced compared to in wild-type mice
• T cell transition to double positive is partially blocked

limbs/digits/tail

hematopoietic system
• the ratio of CD4 over CD8 T cells is reduced compared to in wild-type mice
• T cell transition to double positive is partially blocked

embryogenesis
• mice are born with non-lethal neural tube defects at the lumbosacral region over which skin grows

Mouse Models of Human Disease
OMIM IDRef(s)
Neural Tube Defects 182940 J:103567