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Phenotypes Associated with This Genotype
Genotype
MGI:3776838
Allelic
Composition
Pax1un/Pax1+
Tcf3tm1Cmu/Tcf3tm1Cmu
Genetic
Background
involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax1un mutation (7 available); any Pax1 mutation (19 available)
Tcf3tm1Cmu mutation (0 available); any Tcf3 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die postnatally due to are cannibalization

reproductive system

nervous system
• mice are born with non-lethal neural tube defects at the lumbosacral region over which skin grows

renal/urinary system
• mice exhibit high outflow tract resistance

immune system
• T cell transition to double positive is partially blocked
• the ratio of CD4 over CD8 T cells is reduced compared to in wild-type mice

limbs/digits/tail

hematopoietic system
• T cell transition to double positive is partially blocked
• the ratio of CD4 over CD8 T cells is reduced compared to in wild-type mice

embryo
• mice are born with non-lethal neural tube defects at the lumbosacral region over which skin grows

Mouse Models of Human Disease
OMIM ID Ref(s)
Neural Tube Defects, Susceptibility To; NTD 182940 J:103567


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory