Mouse Genome Informatics
ht
    Pkd1tm1Bdgz/Pkd1+
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
renal/urinary system
• histologically, 30% of animals show cyst formation or tubular dilation; animals with tubular dilation are <24 weeks of age
• when gross morphology is assessed, surface cysts are observed in 19% of mutants, the majority of which are older than 24 weeks; rare animals display cyst development at 6 weeks of age
• histologically, 30% of animals show cyst formation or tubular dilation between 6 and 78 weeks of age

liver/biliary system
• when gross morphology is assessed, surface cysts are observed in 9% of mutants older than 40 weeks (seen in only 1 animal at 42 weeks)

endocrine/exocrine glands
• when gross morphology is assessed, surface cysts are observed in 1% of mutants older than 40 weeks

Mouse Models of Human Disease
OMIM IDRef(s)
Polycystic Kidney Disease 1; PKD1 173900 J:130086