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Phenotypes Associated with This Genotype
Genotype
MGI:3776429
Allelic
Composition		 Notch1tm1Grid/Notch1tm2Rko
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129 * C57BL/6J * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (28 available)
Notch1tm1Grid mutation (0 available); any Notch1 mutation (115 available)
Notch1tm2Rko mutation (3 available); any Notch1 mutation (115 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
increased cochlear inner hair cell number ( J:132241 )
• increases in inner hair cell number are more than in Dll1tm1Gos/Dll1tm2Gos Jag2tm1Grid/Jag2tm1Grid mice
decreased organ of Corti supporting cell number ( J:132241 )
• decreases in inner hair cell number are slightly than in Dll1tm1Gos/Dll1tm2Gos Jag2tm1Grid/Jag2tm1Grid mice or Dll1tm1Gos Jag2tm1Grid homozygotes

nervous system
increased cochlear inner hair cell number ( J:132241 )
• increases in inner hair cell number are more than in Dll1tm1Gos/Dll1tm2Gos Jag2tm1Grid/Jag2tm1Grid mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory