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Phenotypes Associated with This Genotype
Genotype
MGI:3776026
Allelic
Composition		 Krastm4Tyj/Kras+
Tg(Fabp1-cre)1Jig/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Tg(Fabp1-cre)1Jig mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal goblet cell morphology ( J:132357 )
• large, prominent goblet cells develop in the colon
abnormal intestinal epithelium morphology ( J:132357 )
• mice develop widespread hyperplasia throughout the colonic epithelium
• colonic epithelium has a larger transit amplifying cell zone than wild-type; cells in the colonic epithelium have a higher mitotic index than in wild-type
abnormal large intestine crypts of Lieberkuhn morphology ( J:132357 )
• hyperplasia is typified by extreme lengthening of the crypts

endocrine/exocrine glands
abnormal large intestine crypts of Lieberkuhn morphology ( J:132357 )
• hyperplasia is typified by extreme lengthening of the crypts

cellular
abnormal intestinal goblet cell morphology ( J:132357 )
• large, prominent goblet cells develop in the colon

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory