Phenotypes for Eomes MGI:3775736 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Eomes^tm1.1Rob/Eomes^tm1.1Rob
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomes^tm1.1Rob mutation (0 available); any Eomes mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:131055 )

• no embryos are recovered at E7.5

embryo

abnormal trophoblast layer morphology ( J:131055 )

• E7.5 blastocysts after 72 hours in culture either fail to form a a trophoblast outgrowth, or at best, form a rudimentary outgrowth with a few trophoblast giant cells; thus recapitulating the null phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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