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Phenotypes Associated with This Genotype
Genotype
MGI:3775735
Allelic
Composition		 Eomestm1Rob/Eomestm1.1Rob
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (42 available)
Eomestm1.1Rob mutation (0 available); any Eomes mutation (41 available)
Eomestm1Rob mutation (0 available); any Eomes mutation (41 available)
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal endoderm development ( J:131055 )
• specification of the definitive endoderm is disrupted
abnormal visceral endoderm morphology ( J:131055 )
• visceral endoderm fails to displace proximally at E7.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory