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Phenotypes Associated with This Genotype
Genotype
MGI:3775087
Allelic
Composition
Phextm1.2Mkd/Y
Genetic
Background
B6.129-Phextm1.2Mkd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phextm1.2Mkd mutation (0 available); any Phex mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• similar to the decrease in Phexhyp hemizygous male mice at 8 weeks of age
• reduction in renal phosphate uptake at 8 weeks of age is similar to that in Phexhyp hemizygous male mice

renal/urinary system
• reduction in renal phosphate uptake at 8 weeks of age is similar to that in Phexhyp hemizygous male mice

skeleton
• the inner lacunocanalicular wall is buckled and enlarged
• osteocyte lacunae are increased in size and randomly organized compared to those in control bone
• osteomalacia characterized by hyperosteoidosis and an excess of unmineralilized osteoid
• severity of osteomalacia is similar to that of Phexhyp hemizygous male mice

limbs/digits/tail


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory