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Phenotypes Associated with This Genotype
Genotype
MGI:3774850
Allelic
Composition
Atxn7tm1Hzo/Atxn7+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atxn7tm1Hzo mutation (1 available); any Atxn7 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Altered rod photoreceptor nuclear architecture in Tg(RHO-SCA7)R7EJman/0 and Atxn7tm1Hzo/Atxn7+ mice, but not in Tg(RHO-SCA7)R7NJman/0 mice

mortality/aging

vision/eye
• rod photoreceptors exhibit chromatin decondensation; rod nuclei contain more euchromatin and show a reduced and disorganized heterochromatin territory

nervous system
• rod photoreceptors exhibit chromatin decondensation; rod nuclei contain more euchromatin and show a reduced and disorganized heterochromatin territory

Mouse Models of Human Disease
OMIM ID Ref(s)
Spinocerebellar Ataxia 7; SCA7 164500 J:107098


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory