Mouse Genome Informatics
ht
    Atxn7tm1Hzo/Atxn7+
involves: 129S7/SvEvBrd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Altered rod photoreceptor nuclear architecture in Tg(RHO-SCA7)R7EJman/0 and Atxn7tm1Hzo/Atxn7+ mice, but not in Tg(RHO-SCA7)R7NJman/0 mice

mortality/aging

vision/eye
• rod photoreceptors exhibit chromatin decondensation; rod nuclei contain more euchromatin and show a reduced and disorganized heterochromatin territory

nervous system
• rod photoreceptors exhibit chromatin decondensation; rod nuclei contain more euchromatin and show a reduced and disorganized heterochromatin territory

Mouse Models of Human Disease
OMIM IDRef(s)
Spinocerebellar Ataxia 7; SCA7 164500 J:107098