Phenotypes Associated with This Genotype

Genotype
MGI:3774769

• Allelic Composition: Trp53^tm1Brd/Trp53^tm1Brd
• Genetic Background: NIHOla.129S7-Trp53^tm1Brd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tumor multiplicity and proliferation index in Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs, Trp53^tm1Brd/Trp53^tm1Brd and Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Trp53^tm1Brd/Trp53^tm1Brd mice

neoplasm

decreased incidence of tumors by chemical induction ( J:93298 )

• mutants develop fewer and smaller induced tumors than wild-type or Cdkn2a^tm1Cjsmice, averaging 4 fewer papillomas 10-16 weeks after DMBA/TPA administration than wild-type

decreased tumor growth/size ( J:93298 )

• mutants develop smaller induced tumors than wild-type after DMBA/TPA administration

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:93298 )

• mutants develop fewer and smaller induced tumors than wild-type or Cdkn2a^tm1Cjsmice, averaging 4 fewer papillomas 10-16 weeks after DMBA/TPA administration than wild-type