Analysis Tools
mortality/aging
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• mice exhibit seizures resulting in death by P28
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nervous system
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• seizures are rare at P17
• mice exhibit seizures resulting in death by P28
• seizures occur during waking or during rapid eye movement sleep
• during seizures mice exhibit an ictal electroencephalography (EEG) pattern and abnormal spiking EEG activity
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• during seizures mice exhibit an ictal electroencephalography (EEG) pattern and abnormal spiking EEG activity
• during non rapid eye movement sleep, mice exhibit higher EEG power in the low-frequency range (0.5 to 1.0 Hz) and lower EEG power in the 3.5 to 7 Hz frequency compared to wild-type mice
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behavior/neurological
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• at P17, mice spend 23% less time in non-rapid eye movement (NREM) sleep, 21% more time in waking and a 10% decrease in rapid eye movement sleep (REM)compared to wild-type mice
• mice spend more time in waking during the light phase wild-type and heterozygous mice
• while the number of episodes of NREM are normal, the duration of NREM is reduced compared to in wild-type mice
• at P19, two mice exhibiting similar brain wave patterns as seen at P17 exhibit a 19% and 15% increase in waking time per 24 hours compared to wild-type and heterozygotes, respectively, and a 30% and 28% decrease in NREM sleep per 24 hours
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• seizures are rare at P17
• mice exhibit seizures resulting in death by P28
• seizures occur during waking or during rapid eye movement sleep
• during seizures mice exhibit an ictal electroencephalography (EEG) pattern and abnormal spiking EEG activity
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growth/size/body
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• while normal for the first 2 weeks of life, by P16 mice are smaller than wild-type
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