Phenotypes Associated with This Genotype

Genotype
MGI:3774171

• Allelic Composition: Bmp4^tm1Blh/Bmp4⁺
• Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal eye morphology ( J:82877 )

• Background Sensitivity: incidence of eye abnormalities is much lower on the 129S6/SvEvTac background than on a C57BL/6J background, with only 1 of 12 mice showing persistent vitreous vessels and abnormal pupil/iris

abnormal iris morphology ( J:82877 )

• 1 of 12 mice shows persistent vitreous vessels

persistence of hyaloid vascular system ( J:82877 )

• 1 of 12 mice shows abnormal pupil/iris

reproductive system

decreased primordial germ cell number ( J:53311 )

• fewer primordial germ cells due to a reduced founder population rather than impaired expansion

• estimated 55% reduction in PGC founder population of mice on the 129S/SvEv, Black Swiss mixed background

cellular

decreased primordial germ cell number ( J:53311 )

• fewer primordial germ cells due to a reduced founder population rather than impaired expansion

• estimated 55% reduction in PGC founder population of mice on the 129S/SvEv, Black Swiss mixed background