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Phenotypes Associated with This Genotype
Genotype
MGI:3773447
Allelic
Composition
Ay/A
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A mutation (23 available); any a mutation (367 available)
Ay mutation (12 available); any a mutation (367 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• female mice have a 6-fold gain in weight of BAT compared to littermate controls
• female mice have almost a 7-fold gain in weight of fat pad
• female mice have a greater than 6-fold gain in weight of fat pad
• female mice have almost a 6-fold gain in weight of fat pad
• female mice have almost a 4-fold gain in percentage of body fat compared to littermate controls
• male mice have almost a 1.8-fold gain in percentage of body fat compared to littermate controls

behavior/neurological
• 18 week old mice eat about 1.4 times more food during a 7 day period compared to wild-type controls
• the locomotor activity of mice is about half that of wild-type mice

growth/size/body
• by 23 weeks of age, female mice have almost double the weight compared to their wild-type littermate controls
• female but not male mice have a significant 5% increase in their body length
• mice gain weight at a greater rate than littermate controls starting at six weeks of age

homeostasis/metabolism
• circulating levels of leptin are over 12-fold higher compared to littermate controls

liver/biliary system
• female mice have almost a 2-fold gain in weight of the liver

pigmentation
• mice have a yellow coat color

integument
• mice have a yellow coat color

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:131039


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory