Phenotypes Associated with This Genotype

Genotype
MGI:3773310

• Allelic Composition: Scd1^tm2Ntam/Scd1^tm2Ntam; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: B6.Cg-Speer6-ps1^{Tg(Alb-cre)21Mgn} Scd1^tm2Ntam

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased susceptibility to diet-induced obesity ( J:130441 )

• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced obesity

adipose tissue

decreased white adipose tissue amount ( J:130441 )

• reduced by 51% in mice on a high-sucrose very low-fat diet compared to diet matched controls

abnormal fat pad morphology ( J:130441 )

• on a high carbohydrate diet weights of the gonadal, retroperitioneal, and inguinal fat pads are reduced by about 49% - 59% compared to controls lacking the cre transgene

decreased gonadal fat pad weight ( J:130441 )

• reduced weight on a high carbohydrate diet compared to diet matched controls

decreased inguinal fat pad weight ( J:130441 )

• reduced weight on a high carbohydrate diet compared to diet matched controls

decreased retroperitoneal fat pad weight ( J:130441 )

• reduced weight on a high carbohydrate diet compared to diet matched controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:130441 )

N • unlike global null mice, no difference is seen in plasma glucose and insulin levels, glucose clearance or insulin sensitivity between liver knockout mice and controls on a high carbohydrate diet

decreased susceptibility to diet-induced obesity ( J:130441 )

• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced obesity

decreased circulating glucose level ( J:130441 )

• reduced in mice on a high-sucrose very low-fat diet compared to diet matched controls

• but not in mice on high carbohydrate, high fat, or chow diet

• supplementing the high-sucrose very low-fat diet with oleate prevents the decrease in plasma glucose levels

abnormal gluconeogenesis ( J:130441 )

• impaired production of glucose from pyruvate in mice fed a high-sucrose very low-fat diet

decreased liver glycogen level ( J:130441 )

• reduced glycogen levels in the liver in mice on a high-sucrose very low-fat diet compared to diet matched controls

• supplementing the diet with oleate prevents the decrease in hepatic glycogen levels

abnormal lipid homeostasis ( J:130441 )

• 85% decrease in hepatic lipogenesis in mice on a high carbohydrate diet

• however, cholesterol synthesis is unaffected

increased circulating cholesterol level ( J:130441 )

• develops in mice on a high-sucrose very low-fat diet, probably due to increases in HDL and LDL cholesterol

decreased circulating triglyceride level ( J:130441 )

• in mice on a high carbohydrate diet compared to diet-matched controls

• however, levels are similar to controls in mice on a chow or high fat diet

decreased circulating VLDL triglyceride level ( J:130441 )

• significant reduction in mice on a high carbohydrate or a high-sucrose very low-fat diet compared to diet-matched controls

decreased liver triglyceride level ( J:130441 )

• on a high carbohydrate or diet high-sucrose very low-fat diet, liver triglyceride levels are reduced by 69% or 49%, respectively, compared to controls

• fasted mice refed a fat free high carbohydrate diet have lower liver levels of SCD1 products including palmitoleate and oleate

• supplementing the diet with triolein reduces the decrease in liver triglyceride levels

liver/biliary system

decreased liver glycogen level ( J:130441 )

• reduced glycogen levels in the liver in mice on a high-sucrose very low-fat diet compared to diet matched controls

• supplementing the diet with oleate prevents the decrease in hepatic glycogen levels

decreased liver triglyceride level ( J:130441 )

• on a high carbohydrate or diet high-sucrose very low-fat diet, liver triglyceride levels are reduced by 69% or 49%, respectively, compared to controls

• fasted mice refed a fat free high carbohydrate diet have lower liver levels of SCD1 products including palmitoleate and oleate

• supplementing the diet with triolein reduces the decrease in liver triglyceride levels

decreased susceptibility to diet-induced hepatic steatosis ( J:130441 )

• resistant to high carbohydrate and high-sucrose very low-fat, but not high fat, diet-induced fatty liver development

abnormal liver physiology ( J:130441 )

• block in carbohydrate-induce hepatic lipogenesis

• a high-sucrose very low-fat diet fails to increase the rate of triglyceride secretion, unlike in controls

behavior/neurological

behavior/neurological phenotype ( J:130441 )

N • unlike global null mice, no difference in food intake is seen in mice on a chow diet