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Phenotypes Associated with This Genotype
Genotype
MGI:3773274
Allelic
Composition
GpnmbR150X/GpnmbR150X
Genetic
Background
B6.D2-GpnmbR150X
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GpnmbR150X mutation (3 available); any Gpnmb mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

GpnmbR150X/GpnmbR150X mouse eyes develop a pronounced peripupillary swelling

vision/eye
• mutants develop iris disease that is first noticeable at 6 months of age when eyes develop a pronounced peripupillary swelling accompanied by pronounced accumulation of clump cells on the iris surface
• develop a pigment dispersing iris disease
• the iris surface maintains an overall normal morphology during the fist year, after which it becomes increasingly atrophic

pigmentation
• develop a pigment dispersing iris disease

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pigment dispersion syndrome DOID:0060680 OMIM:600510
J:128215


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory