Mouse Genome Informatics
hm
    GpnmbR150X/GpnmbR150X
B6.D2-GpnmbR150X
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

GpnmbR150X/GpnmbR150X mouse eyes develop a pronounced peripupillary swelling

vision/eye
• mutants develop iris disease that is first noticeable at 6 months of age when eyes develop a pronounced peripupillary swelling accompanied by pronounced accumulation of clump cells on the iris surface
• develop a pigment dispersing iris disease
• the iris surface maintains an overall normal morphology during the fist year, after which it becomes increasingly atrophic

pigmentation
• develop a pigment dispersing iris disease

Mouse Models of Human Disease
OMIM IDRef(s)
Glaucoma-Related Pigment Dispersion Syndrome; GPDS1 600510 J:128215