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Phenotypes Associated with This Genotype
Genotype
MGI:3772367
Allelic
Composition
Avy/a
Genetic
Background
involves: C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (178 available); any a mutation (366 available)
Avy mutation (7 available); any a mutation (366 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Spectrum of coat colors in Avy/a mice

growth/size/body

pigmentation
• variable coat color ranging from yellow, mosaic yellow/agouti, or pseudoagouti

neoplasm

integument
• variable coat color ranging from yellow, mosaic yellow/agouti, or pseudoagouti

cellular
• sires mated with a/a dams, but not dams mated with a/a sires, that were supplemented with methyl donors ((folate, choline, betaine, vitamin B12, zinc, and methionine) during pregnancy show a significant shift in the spectrum of color phenotypes toward pseudoagouti, indicating that in utero methyl donor supplementation affects the somatic epigenetic state of the Avy allele only when the allele is derived from the male
• F1 pseudoagouti females that had been exposed to methyl donors in utero from E8.5 to E15.5 and mated to a/a males without further methyl donor supplementation, produce offspring (F2) showing a sift toward pseudoagouti coloration, indicating that diet/environment has an enduring influence on succeeding generations, independent of later changes in diet

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:13142 , J:117156


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory