Mouse Genome Informatics
ht
    Avy/a
involves: C3H/HeJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Spectrum of coat colors in Avy/a mice

growth/size

pigmentation
• variable coat color ranging from yellow, mosaic yellow/agouti, or pseudoagouti

tumorigenesis

integument
• variable coat color ranging from yellow, mosaic yellow/agouti, or pseudoagouti

cellular
• sires mated with a/a dams, but not dams mated with a/a sires, that were supplemented with methyl donors ((folate, choline, betaine, vitamin B12, zinc, and methionine) during pregnancy show a significant shift in the spectrum of color phenotypes toward pseudoagouti, indicating that in utero methyl donor supplementation affects the somatic epigenetic state of the Avy allele only when the allele is derived from the male
• F1 pseudoagouti females that had been exposed to methyl donors in utero from E8.5 to E15.5 and mated to a/a males without further methyl donor supplementation, produce offspring (F2) showing a sift toward pseudoagouti coloration, indicating that diet/environment has an enduring influence on succeeding generations, independent of later changes in diet

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:13142 , J:117156