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Phenotypes Associated with This Genotype
Genotype
MGI:3771551
Allelic
Composition
Meox2tm1(cre)Sor/Meox2+
Slc40a1tm2Nca/Slc40a1tm2Nca
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
Slc40a1tm2Nca mutation (1 available); any Slc40a1 mutation (53 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike homozygous null mice, mice with conditional deletion in embryonic tissues that retain expression in the extraembryonic visceral endoderm and in the placenta survive past birth

hematopoietic system
• severe iron deficient anemia
• at 18 - 22 days of age
• hypochromic at P10
• reduced in both mature erythrocytes and reticulocytes at 18 - 22 days of age
• at 18 - 22 days of age
• at P10
• at P10
• at P10 and at P18 - P22
• significant iron accumulation in splenic macrophages at P12
• at P18 - P22 spleen iron are increased 4.4-fold increase compared to controls

growth/size/body
• apparent within a few days of birth
• difference from controls becomes more prominent with age

homeostasis/metabolism
• significant iron accumulation in duodenal enterocytes at P12
• significant iron accumulation in splenic macrophages at P12
• at P18 - P22 spleen iron are increased 4.4-fold increase compared to controls
• significant iron accumulation in the Kupffer cells and hepatocytes at P12
• at P18 - P22 iron levels in the liver are reduced by 1.7-fold compared to controls

digestive/alimentary system
• significant iron accumulation in duodenal enterocytes at P12

immune system
• significant iron accumulation in splenic macrophages at P12
• at P18 - P22 spleen iron are increased 4.4-fold increase compared to controls

liver/biliary system
• significant iron accumulation in the Kupffer cells and hepatocytes at P12
• at P18 - P22 iron levels in the liver are reduced by 1.7-fold compared to controls

integument
• apparent within a few days of birth
• difference from controls becomes more prominent with age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory