Mouse Genome Informatics
ht
    Slc40a1tm1Nca/Slc40a1+
involves: 129S4/SvJae * 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
N
• at 3 and 6 months of age mice are not anemic despite disrupted iron homeostasis (J:129846)
• at 6 months of age, reticulocytes and mature erythrocytes have reduced cellular hemoglobin
• at 12 months of age hemoglobin content of erythrocytes remains reduced compared to wild-type controls
• at 6 months of age, reticulocytes and mature erythrocytes have reduced cell volume
• at 12 months of age mean cell volume of erythrocytes remains reduced compared to wild-type controls
• at 12 months of age spleen iron content is increased compared to controls

homeostasis/metabolism
• at 12 months of age spleen iron content is increased compared to controls
• significant reduction in liver non-heme iron at 6 and 12 months of age

immune system
• at 12 months of age spleen iron content is increased compared to controls

liver/biliary system
• significant reduction in liver non-heme iron at 6 and 12 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Hemochromatosis, Type 4; HFE4 606069 J:129846