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Phenotypes Associated with This Genotype
Genotype
MGI:3771550
Allelic
Composition
Slc40a1tm1Nca/Slc40a1+
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1tm1Nca mutation (0 available); any Slc40a1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• at 3 and 6 months of age mice are not anemic despite disrupted iron homeostasis (J:129846)
• at 3 and 6 months of age mice are not anemic despite disrupted iron homeostasis (J:129846)
• at 6 months of age, reticulocytes and mature erythrocytes have reduced cellular hemoglobin (J:129846)
• at 12 months of age hemoglobin content of erythrocytes remains reduced compared to wild-type controls (J:129846)
• at 6 months of age, reticulocytes and mature erythrocytes have reduced cellular hemoglobin (J:129846)
• at 12 months of age hemoglobin content of erythrocytes remains reduced compared to wild-type controls (J:129846)
• at 6 months of age, reticulocytes and mature erythrocytes have reduced cell volume (J:129846)
• at 12 months of age mean cell volume of erythrocytes remains reduced compared to wild-type controls (J:129846)
• at 6 months of age, reticulocytes and mature erythrocytes have reduced cell volume (J:129846)
• at 12 months of age mean cell volume of erythrocytes remains reduced compared to wild-type controls (J:129846)
• at 12 months of age spleen iron content is increased compared to controls (J:129846)
• at 12 months of age spleen iron content is increased compared to controls (J:129846)

homeostasis/metabolism
• at 12 months of age spleen iron content is increased compared to controls (J:129846)
• at 12 months of age spleen iron content is increased compared to controls (J:129846)
• significant reduction in liver non-heme iron at 6 and 12 months of age (J:129846)
• significant reduction in liver non-heme iron at 6 and 12 months of age (J:129846)

immune system
• at 12 months of age spleen iron content is increased compared to controls (J:129846)
• at 12 months of age spleen iron content is increased compared to controls (J:129846)

liver/biliary system
• significant reduction in liver non-heme iron at 6 and 12 months of age (J:129846)
• significant reduction in liver non-heme iron at 6 and 12 months of age (J:129846)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Hemochromatosis, Type 4; HFE4 606069 J:129846


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory