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Phenotypes Associated with This Genotype
Genotype
MGI:3771550
Allelic
Composition
Slc40a1tm1Nca/Slc40a1+
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc40a1tm1Nca mutation (0 available); any Slc40a1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• at 3 and 6 months of age mice are not anemic despite disrupted iron homeostasis
• at 6 months of age, reticulocytes and mature erythrocytes have reduced cellular hemoglobin
• at 12 months of age hemoglobin content of erythrocytes remains reduced compared to wild-type controls
• at 6 months of age, reticulocytes and mature erythrocytes have reduced cell volume
• at 12 months of age mean cell volume of erythrocytes remains reduced compared to wild-type controls
• at 12 months of age spleen iron content is increased compared to controls

homeostasis/metabolism
• at 12 months of age spleen iron content is increased compared to controls
• significant reduction in liver non-heme iron at 6 and 12 months of age

immune system
• at 12 months of age spleen iron content is increased compared to controls

liver/biliary system
• significant reduction in liver non-heme iron at 6 and 12 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
NOT hemochromatosis DOID:2352 OMIM:231100
OMIM:235200
OMIM:602390
OMIM:604250
OMIM:606069
OMIM:613313
J:129846


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory