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Phenotypes Associated with This Genotype
Genotype
MGI:3771312
Allelic
Composition		 Rps6kb1tm1Gtho/Rps6kb1tm1Gtho
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rps6kb1tm1Gtho mutation (1 available); any Rps6kb1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
decreased skeletal muscle fiber diameter ( J:129852 )
• the reduction in muscle cell diameter observed is comparable to that observed in Rps6kb1tm1Gtho Rps6kb2tm1Gtho homozygotes
• however, muscle cell size could be rescued by transfection of a constitutively active AMPK

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory